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Are these WordPress tables protected so as to add indexes to?

"dbmain"    "wp_usermeta"   "user_id"   "Not indexed"
"dbmain"    "wp_termmeta"   "term_id"   "Not indexed"
"dbmain"    "wp_commentmeta"    "comment_id"    "Not indexed"
"dbmain"    "wp_comments"   "comment_post_ID"   "Not indexed"
"dbmain"    "wp_comments"   "user_id"   "Not indexed"
"dbmain"    "wp_postmeta"   "post_id"   "Not indexed"
"dbmain"    "wp_mf_post_meta"   "post_id"   "Not indexed"
"dbmain"    "wp_term_relationships" "term_taxonomy_id"  "Not indexed"
"dbmain"    "wp_posts"  "guid"  "Not indexed"
"dbmain"    "wp_mf_custom_fields"   "custom_group_id"   "Not indexed"

These tables aren’t listed, and I used to be questioning if it is protected to index them. I believe some jobs replace and insert rows to a few of these tables, however I’m pondering to index them. I’m not precisely certain the right way to examine if this could increase efficiency through the peak hours though I think it to be the case, as a result of on first inspection I do not actually see a variety of UPDATE or INSERT statements after logging all queries. Is that this protected and is there some strategy to examine utilizing WordPress or another strategies?