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How best to handle database version dependence (from $wp_db_version)

I’m working on a plugin to speed up WordPress queries by adding / changing indexes on WordPress tables.

My question is this: should I make my plugin refuse to work if the database version in $wp_db_version is greater than what I’ve tested with? It’s now at 49752.

It seems from wp-admin/includes/upgrade.php that the core team sometimes adds or changes indexes, but that they haven’t done so since the 4-byte utfmb4 character set came along.

What’s the core team discipline for updating the database version number? In the past, have database updates appeared in the beta releases? (Giving me a chance to test my stuff before the release goes live.)